郝健专注以克雷伯氏菌为细胞工厂，研究该菌生产化学品的能力。
2010-08~今，上海高等研究院, 副研究员，研究员
2018-11~今，伦敦大学学院，牛顿高级学者
2007-12~2008-12，伦敦大学学院，博士后研究员
2003-09~2007-01，清华大学，化学工程系，博士研究生
1. 合成生物学
2. 生物制造
1. 上海高价值专利运营大赛金奖，2024。
2 牛顿高级学者, 2018，英国皇家学会。
3. 中英优秀青年奖学金, 2007，国家留学基金委。
4. 生物法耦合生产生物柴油和1,3-丙二醇的应用基础研究, 2006，中国石油和化学工业协会科技进步一等奖
1. 中国科学院战略性先导科技专项(C类)，XDC0110202，关键化工材料产品生产菌种创建，2023.9-2026.8，项目负责人，200万元。
2. 上海市自然科学基金，23ZR1471100，Pdu微室在克雷伯氏菌代谢甘油合成1,3-丙二醇中的功能研究，2023.4-2026.3，项目负责人，20万元。
3. 中国科学院-韩国国家科技理事会协议项目，184131KYSB20200029，生物法生产异丁醇，2021.1-2022.12，项目负责人，30万元。
4. 国家重点研发计划，中国和韩国政府间产业技术研发合作项目，2019YFE0196900，生物法生产1,3-丙二醇，2020.12-2022.11，项目负责人，71.5万元。
5. 上海市自然科学基金，2019.7-2022.6 19ZR1463600，克雷伯氏菌天然异丁醇合成途径的代谢机理研究，项目负责人，20万元。
6. 英国皇家学会牛顿高级学者基金（Royal Society-Newton Advanced Fellowship grant），NAF\R2\180721，Combined engineering ａｎｄ biological approaches to improve the efficiency of isobutanol production, 2018.11-2021.10， 项目负责人，9.56万英镑。
1. 文章：
[1] Wang Wenqi, et al. Improving isobutanol and 2-ketoisovalerate production by reducing by-product synthesis in Klebsiella pneumoniae. Enzyme and Microbial Technology, 2026, 197: 1-12
[2] Sun Shaoqi, et al. 1,3-Propanediol production by Klebsiella pneumoniae ∆dhaM∆ptsG∆glpK using glucose and glycerol as co-substrates. Microbial Cell Factories. 2026. 25:13.
[3] Cai Yaoyu, et al. Mechanism of metabolites distribution between 2,3-butanediol and branched-chain amino acid synthesis pathways in Klebsiella pneumoniae. J Biotech. 2025, 404: 175-18
[4] Jiang Weiyan, et al. Inactivation of hydrogenase-3 leads to enhancement of 1,3-propanediol and 2,3-butanediol production by Klebsiella pneumoniae. Enzyme Microb Tech. 2024,110438
[5] Wang Qinghui, et al. 2-hydroxyisovalerate production by Klebsiella pneumoniae. Enzyme Microb Tech. 2024, 172:110330
[6] Shu Lin, et al. The pyruvate decarboxylase activity of IpdC is a limitation for isobutanol production by Klebsiella pneumoniae. Biotech Biofuels and Bioproducts 2022, 15:41
[7] Wang Qinghui, et al. . Blocking the 2,3-butanediol synthesis pathway of Klebsiella pneumoniae resulted in L-valine production. World J Microb and Biotech 2022, 38:81
[8] Shu Lin, et al. The roles of diol dehydratase from pdu operon on glycerol catabolism in Klebsiella pneumoniae. Enzyme Microb Tech. 2022, 157: 110021
[9] Sun Shaoqi, et al. 1,2 Propanediol production from glycerol via an endogenous pathway of Klebsiella pneumoniae. Appl Microb Biotech. 2021, 105: 9003-9016
[10] Sun Shaoqi, et al. Redirection of the central metabolism of Klebsiella pneumoniae towards dihydroxyacetone production. Microb Cell Factories. 2021, 20: 123
[11] Yang Yang, et al. Production of 2,3-dihydroxyisovalerate by Enterobacter cloacae. Enzyme Microb Tech. 2020: 109650
[12] Lu Xiyang, et al. Ethylene glycol and glycolic acid production by wild-type Escherichia coli. Biotech Applied Biochem. 2021, 68: 744-755
[13] Wang Yike, et al. 2,3-Dihydroxyisovalerate production by Klebsiella pneumoniae. Applied Microb Biotech 2020, 104: 6601-6613
[14] Zhang Zhongxi, et al. Ethylene glycol and glycolic acid production from xylonic acid by Enterobacter cloacae. Microb Cell Factories. 2020, 19:89
[15] Wei Dong, et al. Non-capsulated mutants of a chemical-producing Klebsiella pneumoniae strain. Biotech Letter 2018, 40: 1-9
[16] Gu Jinjie, et al. Isobutanol and 2-ketoisovalerate production by Klebsiella pneumoniae via a native pathway. Metabolic Engineering 2017, 43:71-84
[17] Wei Dong, et al. Production of Chemicals by Klebsiella pneumoniae Using Bamboo Hydrolysate as Feedstock. J Vis Exp. 2017, e55828
[18] Zhou Jidong, et al. The role of the pyruvate acetyl-CoA switch in the production of 1,3-propanediol by Klebsiella pneumoniae. Applied Biochem Biotech, 2017, 181:1199-1210
[19] Wang Chenhong, et al. Production of xylonic acid by Klebsiella pneumoniae. Applied Microb Biotech, 2016, 100, 23, 10055-10063
[20] Wang Dexin, et al. Gluconic acid production by gad mutant of Klebsiella pneumoniae World J Microb Biotech, 2016, 32:132
