DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity----上海高等研究院

中文

DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity

论文题目: DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity
作者: Zhao, Yan; Guo, Linjie; Cao, Shuting; Xie, Mo; Peng, Hongzhen; Li, Jiang; Luo, Shihua; Ma, Lan; Wang, Lihua
刊名: CHEMICAL COMMUNICATIONS
出版年: 2022 卷: 59 文献号: 1359-7345
关键词:
Zhao, Yan; Guo, Linjie; Cao, Shuting; Xie, Mo; Peng, Hongzhen; Li, Jiang; Luo, Shihua; Ma, Lan; Wang, Lihua
摘要:
We devise a class of amphiphilic drug complexes by programming hydrophobic drug patterns (HDPs) on DNA frameworks. We investigate the effect of HDPs on cellular uptake efficiency and drug potency. We achieve enhanced cytotoxicity against tumor cells by using an asymmetric HDP.