性别 男
职称 正高级工程师四级
电子邮件 zhangbg@sari.ac.cn
通讯地址 上海市浦东区海科路99号2号楼5楼
个人网页 https://people.ucas.edu.cn/~zhangbg
招生专业
化学工程与技术;生物与医药;简历
2008年7月于中国科学院研究生院获博士学位,2008年11月至2011年9月中科院上海生命科学研究院从事博士后研究,2011年9月起在中科院上海高等研究院任副研究员和正高级工程师。
研究方向
1. 微生物细胞工厂的代谢调控
2. 重要医药中间体的微生物合成生物技术
获奖及荣誉
上海市浦东明珠人才计划,2023
承担科研项目情况
1. 国家重点研发计划国际合作专项,“农业生产副产物和废弃物高值化利用生物技术开发”,项目负责人,2018.07-2021.06;
2. 国家重点研发计划,“农业废弃物资源化利用机制”,子课负责人, 2017.01-2021.0;
3、 福建省中科院STS重大项目,“生物法高效制备食品级L-酪氨酸产业化技术研究与应用”,课题负责人,2022.03-2025.3;
4、 地方科技攻关,“微生物定向转化植物甾醇制备新型甾药中间体”,项目负责人,2023.01-2025.06;
5、 地方科技攻关,MEC-DF反应器生物催化制氢菌剂及制氢工艺研究,课题负责人,2023.09-2026.04;
6、 地方横向,“生物法制备泛酸钙工艺开发 ” ,项目负责人,2023.06-2026.06;
9. 地方横向,“生物催化法合成 L-肌肽工艺开发” ,项目负责人,2022.11-2028.10;
10. 地方横向,“生物法制备三羟物7α,15α-diOH-DHEA和9α-OH-BA工艺开发 ” 项目负责人,2024.08-2025.08;
11. 地方横向,“高活性糖基转移酶微生物细胞工厂构建”,项目负责人,2021.12-2024.12;
12. 地方横向,“生转催化法转化雄烯二酮(4-AD)制备雄二烯二酮(ADD)工艺开发”,项目负责人,2019.03-2026.03。
代表论著
1. 文章
[1] Functional characterization of two reductase KshBs in Mycobacterium fortuitum and their applications to C9 non-hydroxylated steroid production. Process Biochemistry, 2024,144,256-265; (通讯作者)
[2] Efficient production of 9,22-dihydroxy-23,24-bisnorchol-4-ene-3-one from phytosterol by modifying multiple genes in Mycobacterium fortuitum. Int. J. Mol. Sci. 2024, 25(7), 3579; (通讯作者)
[3] Phytosterol Conversion into C9 Non-hydroxylated Derivatives through Gene Regulation in Mycobacterium fortuitum. Applied Microbiology and Biotechnology, 2023.10.13. doi: 10.1007/s00253-023-12812-w; (通讯作者)
[4] Improving the production of 9α-hydroxy-4-androstene-3,17-dione from phytosterols by 3-ketosteroid-Δ1 -dehydrogenase deletions and multiple genetic modifications in Mycobacterium fortuitum. Microbial Cell Factories,2023,22(53);(通讯作者)
[5] Production of 21?hydroxy?20?methyl?pregna?1,4?dien?3?one by modifying multiple genes in Mycolicibacterium. Applied Microbiology and Biotechnology, 2023,107(5-6):1563-574);(通讯作者)
[6] Functional analysis of acyl-CoA dehydrogenases and their application to C22 steroid production. Applied Microbiology and Biotechnology. 2023,107:3419–3428; (通讯作者)
[7] Whole-Genome Analysis of Mycobacterium neoaurum DSM1381 and the Validation of Two Key Enzymes Affecting C22 Steroid Intermediates in Sterol Metabolism. International Journal of Molecular Sciences. 2023, 24:6148;(通讯作者)
[8] Bioconversion of Phytosterols to 9-Hydroxy-3-Oxo-4,17-Pregadiene-20-Carboxylic Acid Methyl Ester by Enoyl-CoA Deficiency and Modifying Multiple Genes in Mycolicibacterium neoaurum. Applied and Environmental Microbiology,2022,88(22):e0130322); (通讯作者)
[9] Optimized strategy valorizing unautoclaved cottonseed hull as ruminant alternative feeds via solid-state fermentation: Detoxifying polyphenols, restraining hazardous microflora and antibiotic-resistance gene hosts. Environmental Technology & Innovation. 2022,28:102937; (通讯作者)
[10] Production of 9,21-dihydroxy-20-methyl-pregna-4-en-3-one from phytosterols in Mycobacterium neoaurum by modifying multiple genes and improving the intracellular environment. Microbial Cell Factories, 2021,12,6;(通讯作者)
[11] Purification, characterization, and application of a high activity 3-ketosteroid-Δ1-dehydrogenase from Mycobacterium neoaurum DSM 1381.Applied Microbiology and Biotechnology,2019, DOI: 10.1007/s00253-019-09988-5; (通讯作者)
[12] Identification, function, and application of 3-ketosteroid Δ1-dehydrogenase isozymes in Mycobacterium neoaurum DSM 1381 for the production of steroidic synthons. Microbial Cell Factories, 2018,18;17(1):77. doi: 10.1186/s12934-018-0916-9; (通讯作者)
2. 专利
[1] 制备甾体药物中间体雄烯二酮和双降醇的基因工程菌、及制备甾体药物中间体雄烯二酮和双降醇的方法,申请号,:2023103063213
[2] 一种用于生产制备9-OHAD的基因工程菌株、及其制备方法和应用, 申请号, 2023100395556
[3] 一种产甾药前体的基因工程菌及其用途,专利授权号:ZL202210730036X;
[4] 一种产双降醇的基因工程菌及其用途,专利授权号: 2022107293262;
[5] 一种3-甾酮-△1-脱氢酶及其编码基因和应用,授权专利号:ZL201810200187.8。