1. 同步辐射实验方法及应用
2. 蛋白质晶体学

1. 参与中国科学院战略性先导科技专项（B类）一项，同步辐射X射线细聚焦技术及应用，课题骨干(2014-2018)
2. 中国科学院青年创新促进会人才专项 ，项目负责人（2015-2018）
3. 主持国家基金青年项目，同步辐射装置远程实验方法研究，项目负责人(2016-2018)
4. 参与中科院重大科技基础设施维修改造项目，上海光源X射线吸收谱学和生物大分子晶体学线站关键部件维修改造，课题骨干(2016)
5.参与中科院重大科技基础设施维修改造项目， 生物大分子晶体高分辨结构测定和自动化筛选系统，课题骨干（2011）
6. 参与国家重点研发计划项目一项，微小晶体高效结构测定技术研究，课题骨干(2016-2022)
7. 参加上海光源线站工程，P2生物大分子晶体学线站建设，系统负责人(2016-2022)
8. 上海市自然科学基金面上项目，微聚焦X射线对蛋白质晶体辐射损伤的研究，负责人（2021-2024）

[1]Yu, F, etc.al.  Finback : a web-based data collection system at SSRF biological macromolecular crystallography beamlines.Journal of Synchrotron Radiation[J] 2024 31, 378–384
[2]Zhou, YR,etc. al.. Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 ａｎｄ PF-07321332. BIOCHEMICAL ＡＮＤ BIOPHYSICAL RESEARCH COMMUNICATIONS. 2023 657,16-23
[3] Xu, Mengxue, etc.al. Crystal structures of TTHA1265 ａｎｄ TTHA1264/TTHA1265 complex reveal an intrinsic heterodimeric assembly. International Journal of Biological Macromolecules[J]. 2022, 207: 424-433,
[4] 王伟玮, 谢娟娟, 宋吴涛, 刘喜朋, 汪启胜. Sulfolobus acidocaldarius DHH超家族核酸酶Saci0542的酶学特征研究. 微生物学报[J]. 2022, 62(2): 556-566
[5] Qin, Jiangping,etc.al.. Protein Crystal Instance Segmentation Based on Mask R-CNN. CRYSTALS[J]. 2021, 11(2)
[6] Qin, Wei,etc.al.. Complex crystal structure determination ａｎｄ anti-non-small-cell lung cancer activity of the Hsp90(N) inhibitor Debio0932. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY[J]. 2021, 77: 86-97
[7] Pan, Yongbing, etc.al.. Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries. CELL DISCOVERY[J]. 2021, 7(1)
[8] Li, HuiJin, etc.al.. Anti-NSCLC activity ｉｎ vitro of Hsp90(N) inhibitor KW-2478 ａｎｄ complex crystal structure determination of Hsp90(N)-KW-2478. JOURNAL OF STRUCTURAL BIOLOGY[J]. 2021, 213(2)
[9] Zhou, Xuelan, etc.al.. Structure of SARS-CoV-2 main protease ｉｎ the apo state. SCIENCE CHINA-LIFE SCIENCESnull. 2021, 64(4): 656-659
[10] Han, Yufei, etc.al. Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism. NATURE COMMUNICATIONS[J]. 2021, 12(1)
[11] Wang, Weiwei, etc.al.. Crystal structure details of Vibrio fischeri DarR ａｎｄ mutant DarR-M202I from LTTR family reveals their activation mechanism. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2021, 183: 2354-2363
[12] Liang, Miao, etc.al.. Microplates for Crystal Growth ａｎｄ ｉｎ situ Data Collection at a Synchrotron Beamline. CRYSTALS[J]. 2020, 10(9)
[13] Li Wei, etc.al. SiO2-Mediated High-efficiency Enrichment of 5 nm Gold Nanoparticles ａｎｄ Their Catalytic Activity. ACTA CHIMICA SINICA[J]. 2020, 78(2): 170-176
[14] He, Wei, etc.al.. Autophagy changes ｉｎ lung tissues of mice at 30 days after carbon black-metal ion co-exposure. CELL PROLIFERATION[J]. 2020, 53(7)
[15] Du, Shuo, etc.al. Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy ｉｎ Severely Infected Hamsters ａｎｄ Provides a Potent Cocktail Pairing Strategy. CELL[J]. 2020, 183(4): 1013-+,
[16] Wang, Qihui,etc.al.. Structural ａｎｄ Functional Basis of SARS-CoV-2 Entry by Using Human ACE2. CELL[J]. 2020, 181(4): 894-+
[17] Zhao, FengZhu, etc.al.. A novel sample delivery system based on circular motion for ｉｎ situ serial synchrotron crystallography. LAB ON A CHIP[J]. 2020, 20(21): 3888-3898
[18] Yu, Feng, etc.al.. Aquarium: an automatic data-processing ａｎｄ experiment information management system for biological macromolecular crystallography beamlines. JOURNAL OF APPLIED CRYSTALLOGRAPHY[J]. 2019, 52(2): 472-477
[19] Qisheng Wang, etc.al.. An integrated remote data collection system for macromolecular crystallography beamline at SSRF. NUCLEAR INST. ＡＮＤ METHODS ＩＮ PHYSICS RESEARCH, A. 2019, 42-45